Hunters engaging with Wyoming's Area 21 emphasize the need to be prepared for high hunting pressure and challenging terrain, particularly with dense deadfall that necessitates tools like chainsaws. Insightful advice includes moving early in the season to avoid crowds, and getting away from roads to better locate elk, as they retreat into less accessible areas whenever hunting pressure is high. Important logistical notes include the benefits of using an ATV or truck, and camping being feasible with accessible spots near roads. Overall, while the unit poses challenges like increased hunter density, it's noted as a worthy and rewarding experience for those willing to put in the effort, particularly for archery hunters seeking good opportunities.