Area 43, also referred to as Cooper Lake is located in the southeast corner of the state, northwest of Laramie. Comprised of high plains desert and some riparian river bottoms, this unit contains some BLM and State lands. It is bordered by U.S. Highway 287 on the east, Interstate 80 on the south and Rock River on the west.

Good numbers of antelope are found here but the lack of public access can be a big hurdle. There are some large wildlife management areas that do increase access options.

There are a lot of different types of grassy and desert-like open prairie with big basins, creek bottoms and rolling hills that are good for putting on stalks. There are also private ranch and farm lands that can bring in antelope from the surrounding prairies.

Vegetation here has high desert prairie with sagebrush and grasslands. Riparian areas of creek bottoms can also be grazing areas for nice bucks.

Public access in this unit is tough with only a few county roads. Smaller two tracks can be found, but are usually private. Most county roads are well maintained, with the smaller two-track roads only passable with four-wheel drive or ATVs.

Laramie is the closest town, and has a lot of lodging options. Grocery stores, gas stations and other amenities can be found here as well. Camping is allowed on all public ground for up to 16 days in one location. Hunters can also camp in remote locations.