Hunters discussing Unit 59 - Snake River in Oregon highlight the importance of knowing the terrain, which is rugged and can be challenging to navigate, particularly during certain weather conditions. A common piece of advice is to prepare for the physical demands by ensuring fitness levels are suited for steep hikes and scouting trips. Hunters also mention that understanding the seasonal patterns of game movement can significantly improve success rates, particularly during transition periods. Overall, the unit offers rewarding hunting opportunities for those who are well-prepared and informed about the local terrain and game behavior.