This unit is north and west of units 45B and 45C. All three comprise Kofa National Wildlife Refuge, which is open to hunting but subject to regulations about firearms in vehicles.

Sheep in this unit had reached an all-time low back in 2009, but numbers have rebounded and sheep numbers are more than double what they were a decade ago. Mule deer herds have not bounced back, however, and hunter success is low.

Rocky terrain and several sheer cliffs make for physically difficult sheep hunting. Elevations vary greatly in short distances.

Palo Verde mesquite, catclaw acacia and ironwood grow throughout the unit with riparian desert vegetation growing along stream beds.

The entire unit is in Kofa National Wildlife Refuge, which is open to hunting by holders of sheep or deer tags. Before hunting, familiarize yourself with regulations by visiting The U.S. Fish and Wildlife Service. Be especially aware of regulations that dictate how weapons can be transported in vehicles. A scarcity of roads can result in lengthy hikes. The best sheep habitat can be accessed from Highway 95 and communication tower roads.

Hunters camp along dirt roads. Lodging and services are in Quartzsite and Brenda. Privately owned, developed campgrounds are in Brenda and Quartzite.