Centered near Globe, AZ, this unit encompasses hundreds of square miles of Coues deer and mule deer habitat. Additionally, a few elk and small bands of Rocky Mountain bighorn sheep inhabit the unit. The majority of the terrain is rugged and steep, and some places have such dense manzanita brush that hiking through it can be difficult. This eastern boundary of the unit is the San Carlos Indian Reservation.

This unit is well-known for Coues deer hunting with some bucks reaching trophy size. Mule deer inhabit most of the unit, but in lower numbers than the Coues deer. This unit shares a small population of Rocky Mountain bighorn sheep with Unit 23, where the two units border each other along the Salt River. Elk are scarce, but hunting can be decent during early rifle seasons when hunters can locate bulls by calling and listening for bugles. There are only a few tags issued for elk as a limited opportunity, general season hunt. Black bear numbers are high.