This large unit, located in south-central Alaska, holds a large portion of Denali National Park. The park is not open to hunting with the exception of the Denali National Preserve. A large majority of this unit is public alongside the park but the north half of the unit holds a few large parcels of tribal lands that hunters will not be allowed to hunt on. The Denali Highway provides good access along the northeastern portion of the unit while the Parks Highway provides access along the northwest corner of the area. This area is very mountainous with large river bottoms and drainage separating mountain ranges. Areas along the northern half of the unit see a lot of hunting pressure but some remote locations can be flown or floated into.

Hunting pressure can be high at times but great populations of Dall sheep and grizzlies can be found here.